While it’s impossible to imagine Sidney Prescott being played by anyone other than Neve Campbell, Reese Witherspoon was considered for the role when Wes Craven and Kevin Williamson were developing the project with Dimension Films. She was on a shortlist of other actresses including Molly Ringwald, Brittany Murphy, Melissa Joan Hart and Tori Spelling, but the role ultimately went to Campbell. But why didn’t Witherspoon get the role? According to Digital Spy, she didn’t even audition for the film because she allegedly didn’t want to star in a horror film.
Campbell was actually a last-minute replacement for Sidney as Drew Barrymore was forced to leave the role due to a scheduling conflict. She still appears as Casey Becker in the harrowing opening scene where Ghostface is chasing her home. It’s a shame Witherspoon didn’t take any chances on “Scream,” but the missed opportunity didn’t hurt her career as she’s still an excellent actress who adds an exceptional amount of depth to her work.
There is still time for them to appear in at least “Scream 5” of 2022, but we would strongly doubt that. The new film reunites Campbell, Courteney Cox and David Arquette after “Scream 4” from 2011 and also stars Jack Quaid, Hayden Panettiere and Heather Matarazzo.